An enzyme-responsive controlled release system based on a dual-functional peptide

X Li; S Burger; AJ O'Connor; L Ong; JA Karas; SL Gras

Journal article

An enzyme-responsive controlled release system based on a dual-functional peptide

X Li, S Burger, AJ O'Connor, L Ong, JA Karas, SL Gras

Chemical Communications | Published : 2016

DOI: 10.1039/c5cc10480g

Abstract

A new controlled release system was developed by loading a dual-functional peptide (DFP) on a mesoporous silica material. One-pot synthesis produced a DFP that was stimuli responsive, releasing a therapeutic peptide by protease cleavage. The design provides new steps towards smart biomaterials.

University of Melbourne Researchers

Xu Li Author

Andrea O'Connor Author

Lydia Ong Author

John Karas Author

Related Projects (1)

DAIRY INNOVATION HUB: TRANSFORMATIONAL RESEARCH TO UNDERPIN THE FUTURE OF THE AUSTRALIAN DAIRY MANUFACTURING INDUSTRY (PROJECT 2A)

The University of Melbourne, The University of Queensland and Dairy Innovation Australia will join in this Research Hub to address significa..

Grants

Awarded by ARC Dairy Innovation Hub

Awarded by Australian Research Council

Funding Acknowledgements

We thank P. O'Donnell and C. S. Ang of The Bio21 Mass Spectrometry and Proteomics Facility for help with peptide characterisation; K. Ladewig and K. Abberton for advice on MMP; S. Boskovic for the code to determine the pore size distributions; R. Curtain of The University of Melbourne Advanced Microscopy Facility for SEM support; the PFPC for infrastructure access. X. Li is supported by a McKenzie fellowship and S. Gras by the ARC Dairy Innovation Hub IH120100005.